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The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity
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https://doi.org/10.1038/nsmb.1738Abstract
The voltage-gated proton channel Hv1 forms a dimer, but each monomer contains a voltage sensor domain that forms a pore for proton conduction. Now functional work using voltage clamp fluorometry, current recording and modeling reveals that the 2 pores are gated in a cooperative manner.
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