The UCLA Depression Grand Challenge is a groundbreaking campuswide initiative to cut the global burden of depression on human health and well-being in half by 2050. Established by Chancellor Gene Block in 2015, UCLA is using an interdisciplinary approach leveraging its own expertise and collaborating with outside entities representing academic, government, philanthropic and industry sectors to bring new understanding and treatments to the greatest health challenge of the 21st century. Currently, the DGC is focused on discovering the types and causes of depression, developing new treatments and putting new knowledge and strategies into practice, especially for communities underserved by current systems and methods.