This study examines the capabilities and limitations of the fifth-generation Pennsylvania State University-National Center for Atmospheric Research Mesoscale Model (MM5) in predicting the precipitation and circulation features that accompanied the 2004 North American monsoon (NAM). When the model is reinitialized every 5 days to restrain the growth of modeling errors, its results for precipitation checked at subseasonal time scales (not for individual rainfall events) become comparable with ground- and satellite-based observations as well as with the NAM's diagnostic characteristics. The modeled monthly precipitation illustrates the evolution patterns of monsoon rainfall, although it underestimates the rainfall amount and coverage area in comparison with observations. The modeled daily precipitation shows the transition from dry to wet episodes on the monsoon onset day over the Arizona-New Mexico region, and the multiday heavy rainfall (>1 mm day-1) and dry periods after the onset. All these modeling predictions agree with observed variations. The model also accurately simulated the onset and ending dates of four major moisture surges over the Gulf of California during the 2004 monsoon season. The model reproduced the strong diurnal variability of the NAM precipitation, but did not predict the observed diurnal feature of the precipitation peak's shift from the mountains to the coast during local afternoon to late night. In general, the model is able to reproduce the major, critical patterns and dynamic variations of the NAM rainfall at intraseasonal time scales, but still includes errors in precipitation quantity, pattern, and timing. The numerical study suggests that these errors are due largely to deficiencies in the model's cumulus convective parameterization scheme, which is responsible for the model's precipitation generation. © 2007 American Meteorological Society.

In the PILPS 2(e) experiment, the Snow Atmosphere Soil Transfer (SAST) land-surface scheme developed from the Biosphere-Atmosphere Transfer Scheme (BATS) showed difficulty in accurately simulating the patterns and quantities of runoff resulting from heavy snowmelt in the high-latitude Torne-Kalix River basin (shared by Sweden and Finland). This difficulty exposes the model deficiency in runoff formations. After representing subsurface runoff and calibrating the parameters, the accuracy of hydrograph prediction improved substantially. However, even with the accurate precipitation and runoff, the predicted soil moisture and its variation were highly "model-dependent". Knowledge obtained from the experiment is discussed. © 2003 Elsevier Science B.V. All rights reserved.

Estimating the water budgets in a small-scale basin is a challenge, especially in the mountainous western United States, where the terrain is complex and observational data in the mountain areas are sparse. This manuscript reports on research that downscaled 5-yr (1999-2004) hydrometeorological fields over the upper Rio Grande basin from a 2.5° NCEP-NCAR reanalysis to a 4-km local scale using a regional climate model [fifth-generation Pennsylvania State University-National Center for Atmospheric Research Mesoscale Model (MM5), version 3]. The model can reproduce the terrain-related precipitation distribution - the trend of diurnal, seasonal, and interannual precipitation variability - although poor snow simulation caused it to overestimate precipitation and evapotranspiration in the cold season. The outcomes from the coupled model are also comparable to offline Variable Infiltration Capacity (VIC) and Land Data Assimilation System (LDAS)/Mosaic land surface simulations that are driven by observed and/or analyzed surface meteorological data. © 2007 American Meteorological Society.

This study downscaled more than five years of data (1999-2004) for hydrometeorological fields over the upper Rio Grande basin (URGB) to a 4-km resolution using a regional model [fifth-generation Pennsylvania State University-National Center for Atmospheric Research (NCAR) Mesoscale Model (MM5, version 3)] and two forcing datasets that include National Centers for Environmental Prediction (NCEP)-NCAR reanalysis-1 (R1) and North America Regional Reanalysis (NARR) data. The long-term high-resolution simulation results show detailed patterns of hydroclimatological fields that are highly related to the characteristics of the regional terrain; the most important of these patterns are precipitation localization features caused by the complex topography. In comparison with station observational data, the downscaling processing, on whichever forcing field is used, generated more accurate surface temperature and humidity fields than the Eta Model and NARR data, although it still included marked errors, such as a negative (positive) bias toward the daily maximum (minimum) temperature and overestimated precipitation, especially in the cold season. Comparing the downscaling results forced by the NARR and R1 with both the gridded and station observational data shows that under the NARR forcing, the MM5 model produced generally better results for precipitation, temperature, and humidity than it did under the R1 forcing. These improvements were more apparent in winter and spring. During the warm season, although the use of NARR improved the precipitation estimates statistically at the regional (basin) scale, it substantially underestimated them over the southern upper Rio Grande basin, partly because the NARR forcing data exhibited warm and dry biases in the monsoon-active region during the simulation period and improper domain selection. Analyses also indicate that over mountainous regions, both the Climate Prediction Center's (CPC's) gridded (0.25°) and NARR forcings underestimate precipitation in comparison with station gauge data. © 2008 American Meteorological Society.

In this study, the impact of rainfall assimilation on the forecasts of convective rainfall over the mountainous areas in the southwestern United States is investigated. The rainfall is derived from the U.S. Weather Surveillance Radar-1988 Doppler (WSR-88D) radar network, and the fifth-generation Mesoscale Model (MM5) Four-Dimensional Variational (4DVAR) system is employed in the study. We evaluate the rainfall assimilation skill through two rainstorm events (5-6 August and 11-12 September 2002) that occurred over the southwestern United States in 2002. A series of experiments for the two cases is conducted. The results show that the minimization process in the 4DVAR is sensitive to the length of assimilation window and error variance in the observation data. Assimilation of rainfall can produce a better short-range precipitation forecast. However, the time range of improved forecasts is limited to about 15 hours with the model resolution of 20 km. It is indicated that rainfall assimilation produces more realistic moisture divergence and temperature fields in the initial conditions for the two cases. Therefore the forecast of rainstorms is closer to observations in both quantity and pattern. Copyright 2006 by the American Geophysical Union.

The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular restenosis and nephrotic hypertrophy. Although mTOR inhibitor, rapamycin, has been widely used to inhibit the aberrant signaling due to mTOR activation that plays a major role in hyperproliferative diseases, in some cases rapamycin does not attenuate the cell proliferation and survival. Thus, we studied the mechanism(s) by which cells may confer resistance to rapamycin. Our data show that in a variety of cell types the mTOR inhibitor rapamycin activates extracellularly regulated kinases (Erk1/2) signaling. Rapamycin-mediated activation of the Erk1/2 signaling requires (a) the epidermal growth factor receptor (EGFR), (b) its tyrosine kinase activity and (c) intact autophosphorylation sites on the receptor. Rapamycin treatment increases tyrosine phosphorylation of EGFR without the addition of growth factor and this transactivation of receptor involves activation of c-Src. We also show that rapamycin treatment triggers activation of cell survival signaling pathway by activating the prosurvival kinases Erk1/2 and p90RSK. These studies provide a novel paradigm by which cells escape the apoptotic actions of rapamycin and its derivatives that inhibit the mTOR pathway.

Using the MM5-4DVAR system, a monsoon rainstorm case over southern Arizona (5-6 August 2002) was investigated for the influence of assimilating satellite rainfall estimates on precipitation forecasts. A set of numerical experiments was conducted with multiple configurations including using 20-km or 30-km grid distances and none or 3-h or 6-h assimilation time windows. Results show that satellite rainfall assimilation can improve the rainstorm-forecasting pattern and amount to some extent. The minimization procedure of 4DVAR is sensitive to model spatial resolution and the assimilation time window. The 3-h assimilation window with hourly rainfall data works well for the 6-h forecast, and for 12-h or longer forecasts, a 6-h assimilation window will be requested. Copyright 2004 by the American Geophysical Union.

In this article, four continually processed sea surface temperature (SST) datasets, including the Reynolds SST (RYD), the global final analysis of skin temperature at oceans (FNL), and two Moderate Resolution Imaging Spectroradiometer (MODIS) Aqua SSTs retrieved from thermal infrared imagery (TIR) and midinfrared imagery (MIR), were compared. The results show variations from each other. In comparison with the RYD SST, the FNL data have -0.5° ∼ 0.5°C perturbations, while the TIR and MIR SSTs possess larger deviations of -2° ∼ 1°C, mainly due to algorithm and/or sensor differences in these SST datasets. A regional model, the fifth-generation Pennsylvania State University-Na tional Center for Atmospheric Research (Penn State-NCAR) Mesoscale Model (MM5), was used to investigate whether model atmospheric predictions, especially those concerning precipitation during the North American monsoon season, are sensitive to these SST variations. A comparison of rainfall, atmospheric height, temperature, and wind fields produced by model results, reanalysis data, and observations indicates that, at monthly scale, the model shows changes in the simulations for three consecutive years; in particular, rainfall amounts, timing, and even patterns vary at some specific regions. Forced by the MODIS Aqua midinfrared SST (MIR), which includes large regions with SST values lower than the conventional Reynolds SST, the MM5 rain field predictions show reduced errors over land and oceans compared to when the model is forced by other SST data. Specifically, rainfall estimates are improved over the offshore of southern Mexico, the Gulf of Mexico, the coastal regions of southern and eastern Mexico, and the southwestern U.S. monsoon active region, but only slightly improved over the monsoon core and the high-elevated Great Plains. Using MIR SST data, one is also capable of improving geopotential height and temperature fields in comparison wit he reanalysis data. © 2005 American Meteorological Society.

The impact of assimilating rainfall derived from radar and satellites on rainstorm forecasts over the Southwestern United States is discussed. The major advantage of 4DVAR is the use of full model dynamics and physics to assimilate multiple-time-level observation data. Rainfall assimilation via 4DVAR is used to improve the moisture distributions in model IC. It is found that by using 4DVAR to generate model IC, the precipitation intensity and patterns can be improved substantially over the mid-latitude plain regions.