Allergic contact dermatitis related to para-phenylendiamine (PPD) from temporary black henna tattoos and hair dyes has become an epidemic in recent years. Several cases of adverse skin reactions to PPD have been reported in the literature. Herein, we present a case of angioedema-like allergic contact dermatitis related to hair coloring with henna.
Methylisothiazolinone (MI) is commonly used as a preservative in personal care products and is a frequent cause of allergic contact dermatitis. Wepresent a patient with allergic contact dermatitis caused by MI in hair care products and discuss this allergen to bring attention to this common cause ofcontact dermatitis, and to highlight its frequent use in hair care products. If allergy to MI is suspected, testing should be performed to this individual preservative, as testing solely for the combination preservative,methylisothiazolinone/methylchloroisothiazolinone (Kathon CG®), may miss many cases of MI allergy.
Filaggrin mutations underlie ichthyosis vulgaris and increased risk of atopic dermatitis, conditions typified by disruption of the skin microbiome and cutaneous immune response. Yet, it remains unclear if neonatal skin barrier compromise due to filaggrin deficiency alters the quality of commensal-specific T cells and the functional impact of such responses. To address these questions, we profiled changes in the skin barrier and early cutaneous immune response of neonatal C57BL/6 Flg-/- and WT mice using scRNAseq, flow cytometry and other modalities. Flg-/- neonates showed little alteration in transepidermal water loss or lipid or corneocyte related gene expression. However, they demonstrated increases in barrier disruption genes, epidermal dye penetration and numbers of skin CD4+ T cells. Using an engineered strain of Staphylococcus epidermidis (S. epi-2W) to study the response to neonatal skin colonization, we found that commensal-specific CD4+ T cells were skewed in Flg-/- pups towards effector rather than regulatory T cells. This altered response persisted into adulthood, where it was typified by Th17 cells and associated with increased susceptibility to imiquimod-induced skin inflammation. Thus, subtle but impactful differences in neonatal barrier function in Flg-/- mice are accompanied by a skewed commensal-specific CD4+ response, with enduring consequences for skin immune homeostasis.
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