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Tuning of protease resistance in oligopeptides through N -alkylation

Published Web Location

https://doi.org/10.1039/c8cc04407d
Abstract

N-Methylation of amino acids is an effective way to create protease resistance in both natural and synthetic peptides. However, alkyl substituents other than N-methyl have not been extensively studied. Here, we prepare and examine a series of N-substituted peptides in which the size and length of the alkyl group is modulated. These design insights provide a unique and modular handle for tuning proteolysis in oligopeptides.

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