Global approaches to understanding ubiquitination.
- Author(s): Kaiser, Peter
- Huang, Lan
- et al.
Published Web Locationhttps://doi.org/10.1186/gb-2005-6-10-233
Ubiquitination--the linkage of one or more molecules of the protein ubiquitin to another protein--regulates a wide range of biological processes in all eukaryotes. We review the proteome-wide strategies that are being used to study aspects of ubiquitin biology, including substrates, components of the proteasome and ubiquitin ligases, and deubiquitination.