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Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.

  • Author(s): Murkey, Jamie A;
  • Chew, Kara W;
  • Carlson, Margrit;
  • Shannon, Chelsea L;
  • Sirohi, Deepika;
  • Sample, Hannah A;
  • Wilson, Michael R;
  • Vespa, Paul;
  • Humphries, Romney M;
  • Miller, Steve;
  • Klausner, Jeffrey D;
  • Chiu, Charles Y
  • et al.
Abstract

Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.

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