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Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing

  • Author(s): Murkey, JA
  • Chew, KW
  • Carlson, M
  • Shannon, CL
  • Sirohi, D
  • Sample, HA
  • Wilson, MR
  • Vespa, P
  • Humphries, RM
  • Miller, S
  • Klausner, JD
  • Chiu, CY
  • et al.
Abstract

Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.

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