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Open Access Publications from the University of California

Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.

  • Author(s): Murkey, Jamie A
  • Chew, Kara W
  • Carlson, Margrit
  • Shannon, Chelsea L
  • Sirohi, Deepika
  • Sample, Hannah A
  • Wilson, Michael R
  • Vespa, Paul
  • Humphries, Romney M
  • Miller, Steve
  • Klausner, Jeffrey D
  • Chiu, Charles Y
  • et al.

Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.

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