Skip to main content
Download PDF
- Main
Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis
- Hao, Samantha;
- Abdelghany, Mazin;
- Lyden, Amy;
- Sit, Rene;
- Tan, Michelle;
- Tato, Cristina M;
- DeRisi, Joseph L;
- Miller, Steve;
- Doernberg, Sarah B;
- Langelier, Charles
Published Web Location
https://doi.org/10.1128/aac.00961-20Abstract
Staphylococcus argenteus is a novel staphylococcal species associated with invasive disease. We report the first case of daptomycin/vancomycin-resistant S. argenteus, initially speciated as Staphylococcus aureus, that developed from repeated treatment with daptomycin for a complex vascular graft infection. Whole-genome sequencing of longitudinally collected isolates identified acquisition of MprF S337L, a mutation predicted to increase surface charge and repel cationic molecules.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.