Skip to main content
eScholarship
Open Access Publications from the University of California

Particulate air pollutants and asthma: A paradigm for the role of oxidative stress in PM-induced adverse health effects

  • Author(s): Li, N
  • Hao, M
  • Phalen, RF
  • Hinds, WC
  • Nel, AE
  • et al.
Abstract

Asthma is a chronic inflammatory disease, which involves a variety of different mediators, including reactive oxygen species. There is growing awareness that particulate pollutants act as adjuvants during allergic sensitization and can also induce acute asthma exacerbations. In this communication we review the role of oxidative stress in asthma, with an emphasis on the pro-oxidative effects of diesel exhaust particles and their chemicals in the respiratory tract. We review the biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma. © 2003 Elsevier Inc. All rights reserved.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View