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Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates
- Okitwi, Martin;
- Orena, Stephen;
- Thomas, Katairo;
- Tumwebaze, Patrick K;
- Byaruhanga, Oswald;
- Nsobya, Samuel L;
- Conrad, Melissa D;
- Bayles, Brett R;
- Rosenthal, Philip J;
- Cooper, Roland A
Published Web Location
https://doi.org/10.1128/aac.01437-21Abstract
We measured susceptibilities of Ugandan Plasmodium falciparum isolates assayed on the day of collection or after storage at 4°C. Samples were incubated with serial dilutions of 8 antimalarials, and susceptibilities were determined from 72-h growth inhibition assays. Storage was associated with decreased growth and lower 50% inhibitory concentration values, but differences between assays beginning on day 0 or after 1 or 2 days of storage were modest, indicating that short-term storage before drug susceptibility determination is feasible.
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