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Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease
- de Hemptinne, Coralie;
- Swann, Nicole C;
- Ostrem, Jill L;
- Ryapolova-Webb, Elena S;
- San Luciano, Marta;
- Galifianakis, Nicholas B;
- Starr, Philip A
Published Web Location
https://doi.org/10.1038/nn.3997Abstract
By examining Parkinson's disease patients undergoing deep brain stimulation (DBS) implantation surgery, this study shows that therapeutic DBS acts on the primary motor cortex to reversibly reduce excessive coupling between the phase of the beta rhythm and the amplitude of broadband activity over a similar time course as the reduction in parkinsonian motor signs.
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