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Open Access Publications from the University of California

Evaluation of the malnutrition-inflammation score in kidney transplant recipients.

  • Author(s): Molnar, Miklos Zsolt
  • Keszei, Andras
  • Czira, Maria Eszter
  • Rudas, Anna
  • Ujszaszi, Akos
  • Haromszeki, Bela
  • Kosa, Janos Pal
  • Lakatos, Peter
  • Sarvary, Eniko
  • Beko, Gabriella
  • Fornadi, Katalin
  • Kiss, Istvan
  • Remport, Adam
  • Novak, Marta
  • Kalantar-Zadeh, Kamyar
  • Kovesdy, Csaba P
  • Mucsi, Istvan
  • et al.


Chronic protein-energy wasting, termed malnutrition-inflammation complex syndrome, is frequent in patients with chronic kidney disease and is associated with anemia, morbidity, and mortality in patients on maintenance dialysis therapy. The Malnutrition-Inflammation Score (MIS) recently has been developed and validated in dialysis patients.

Study design

Observational cross-sectional study.

Setting & participants

993 prevalent kidney transplant recipients.


MIS computed from change in body weight, dietary intake, gastrointestinal symptoms, functional capacity, comorbid conditions, decreased fat store/Systemic Global Assessment, signs of muscle wasting/Systemic Global Assessment, body mass index, serum albumin level, and serum transferrin level.


Markers of inflammation and malnutrition, including serum C-reactive protein, interleukin 6, tumor necrosis factor alpha, serum leptin, prealbumin, body mass index, and abdominal circumference. The relationship was modeled by using structural equation models.


Mean age was 51 +/- 13 years, 57% were men, and 21% had diabetes. Median time from transplant was 72 months. MIS significantly correlated with abdominal circumference (r = -0.144), serum C-reactive protein level (r = 0.094), serum interleukin 6 level (r = 0.231), and serum tumor necrosis factor alpha level (r = 0.102; P < 0.01 for all). A structural equation model with 2 latent variables (malnutrition and inflammation factor) showed good fit to the observed data.


Single-center study, lack of information about vascular access, presence of nonfunctioning kidney transplant, relatively high refusal rate.


Our results confirm that MIS reflects both energy-protein wasting and inflammation in kidney transplant recipients. This simple instrument appears to be a useful tool to assess the presence of protein-energy wasting in this patient population.

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