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Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II
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https://doi.org/10.1073/pnas.1215241109Abstract
The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription.
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