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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

  • Author(s): Speliotes, Elizabeth K
  • Willer, Cristen J
  • Berndt, Sonja I
  • Monda, Keri L
  • Thorleifsson, Gudmar
  • Jackson, Anne U
  • Lango Allen, Hana
  • Lindgren, Cecilia M
  • Luan, Jian'an
  • Mägi, Reedik
  • Randall, Joshua C
  • Vedantam, Sailaja
  • Winkler, Thomas W
  • Qi, Lu
  • Workalemahu, Tsegaselassie
  • Heid, Iris M
  • Steinthorsdottir, Valgerdur
  • Stringham, Heather M
  • Weedon, Michael N
  • Wheeler, Eleanor
  • Wood, Andrew R
  • Ferreira, Teresa
  • Weyant, Robert J
  • Segrè, Ayellet V
  • Estrada, Karol
  • Liang, Liming
  • Nemesh, James
  • Park, Ju-Hyun
  • Gustafsson, Stefan
  • Kilpeläinen, Tuomas O
  • Yang, Jian
  • Bouatia-Naji, Nabila
  • Esko, Tõnu
  • Feitosa, Mary F
  • Kutalik, Zoltán
  • Mangino, Massimo
  • Raychaudhuri, Soumya
  • Scherag, Andre
  • Smith, Albert Vernon
  • Welch, Ryan
  • Zhao, Jing Hua
  • Aben, Katja K
  • Absher, Devin M
  • Amin, Najaf
  • Dixon, Anna L
  • Fisher, Eva
  • Glazer, Nicole L
  • Goddard, Michael E
  • Heard-Costa, Nancy L
  • Hoesel, Volker
  • Hottenga, Jouke-Jan
  • Johansson, Asa
  • Johnson, Toby
  • Ketkar, Shamika
  • Lamina, Claudia
  • Li, Shengxu
  • Moffatt, Miriam F
  • Myers, Richard H
  • Narisu, Narisu
  • Perry, John RB
  • Peters, Marjolein J
  • Preuss, Michael
  • Ripatti, Samuli
  • Rivadeneira, Fernando
  • Sandholt, Camilla
  • Scott, Laura J
  • Timpson, Nicholas J
  • Tyrer, Jonathan P
  • van Wingerden, Sophie
  • Watanabe, Richard M
  • White, Charles C
  • Wiklund, Fredrik
  • Barlassina, Christina
  • Chasman, Daniel I
  • Cooper, Matthew N
  • Jansson, John-Olov
  • Lawrence, Robert W
  • Pellikka, Niina
  • Prokopenko, Inga
  • Shi, Jianxin
  • Thiering, Elisabeth
  • Alavere, Helene
  • Alibrandi, Maria TS
  • Almgren, Peter
  • Arnold, Alice M
  • Aspelund, Thor
  • Atwood, Larry D
  • Balkau, Beverley
  • Balmforth, Anthony J
  • Bennett, Amanda J
  • Ben-Shlomo, Yoav
  • Bergman, Richard N
  • Bergmann, Sven
  • Biebermann, Heike
  • Blakemore, Alexandra IF
  • Boes, Tanja
  • Bonnycastle, Lori L
  • Bornstein, Stefan R
  • Brown, Morris J
  • Buchanan, Thomas A
  • Busonero, Fabio
  • Campbell, Harry
  • Cappuccio, Francesco P
  • Cavalcanti-Proença, Christine
  • Chen, Yii-Der Ida
  • Chen, Chih-Mei
  • Chines, Peter S
  • Clarke, Robert
  • Coin, Lachlan
  • Connell, John
  • Day, Ian NM
  • den Heijer, Martin
  • Duan, Jubao
  • Ebrahim, Shah
  • Elliott, Paul
  • Elosua, Roberto
  • Eiriksdottir, Gudny
  • Erdos, Michael R
  • Eriksson, Johan G
  • Facheris, Maurizio F
  • Felix, Stephan B
  • Fischer-Posovszky, Pamela
  • Folsom, Aaron R
  • Friedrich, Nele
  • Freimer, Nelson B
  • Fu, Mao
  • Gaget, Stefan
  • Gejman, Pablo V
  • Geus, Eco JC
  • Gieger, Christian
  • Gjesing, Anette P
  • Goel, Anuj
  • Goyette, Philippe
  • Grallert, Harald
  • Grässler, Jürgen
  • Greenawalt, Danielle M
  • Groves, Christopher J
  • Gudnason, Vilmundur
  • Guiducci, Candace
  • Hartikainen, Anna-Liisa
  • Hassanali, Neelam
  • Hall, Alistair S
  • Havulinna, Aki S
  • Hayward, Caroline
  • Heath, Andrew C
  • Hengstenberg, Christian
  • Hicks, Andrew A
  • Hinney, Anke
  • Hofman, Albert
  • Homuth, Georg
  • Hui, Jennie
  • Igl, Wilmar
  • Iribarren, Carlos
  • Isomaa, Bo
  • Jacobs, Kevin B
  • Jarick, Ivonne
  • Jewell, Elizabeth
  • John, Ulrich
  • Jørgensen, Torben
  • Jousilahti, Pekka
  • Jula, Antti
  • Kaakinen, Marika
  • Kajantie, Eero
  • Kaplan, Lee M
  • Kathiresan, Sekar
  • Kettunen, Johannes
  • Kinnunen, Leena
  • Knowles, Joshua W
  • Kolcic, Ivana
  • König, Inke R
  • Koskinen, Seppo
  • Kovacs, Peter
  • Kuusisto, Johanna
  • Kraft, Peter
  • Kvaløy, Kirsti
  • Laitinen, Jaana
  • Lantieri, Olivier
  • Lanzani, Chiara
  • Launer, Lenore J
  • Lecoeur, Cecile
  • Lehtimäki, Terho
  • Lettre, Guillaume
  • Liu, Jianjun
  • Lokki, Marja-Liisa
  • Lorentzon, Mattias
  • Luben, Robert N
  • Ludwig, Barbara
  • MAGIC
  • Manunta, Paolo
  • Marek, Diana
  • Marre, Michel
  • Martin, Nicholas G
  • McArdle, Wendy L
  • McCarthy, Anne
  • McKnight, Barbara
  • Meitinger, Thomas
  • Melander, Olle
  • Meyre, David
  • Midthjell, Kristian
  • Montgomery, Grant W
  • Morken, Mario A
  • Morris, Andrew P
  • Mulic, Rosanda
  • Ngwa, Julius S
  • Nelis, Mari
  • Neville, Matt J
  • Nyholt, Dale R
  • O'Donnell, Christopher J
  • O'Rahilly, Stephen
  • Ong, Ken K
  • Oostra, Ben
  • Paré, Guillaume
  • Parker, Alex N
  • Perola, Markus
  • Pichler, Irene
  • Pietiläinen, Kirsi H
  • Platou, Carl GP
  • Polasek, Ozren
  • Pouta, Anneli
  • Rafelt, Suzanne
  • Raitakari, Olli
  • Rayner, Nigel W
  • Ridderstråle, Martin
  • Rief, Winfried
  • Ruokonen, Aimo
  • Robertson, Neil R
  • Rzehak, Peter
  • Salomaa, Veikko
  • Sanders, Alan R
  • Sandhu, Manjinder S
  • Sanna, Serena
  • Saramies, Jouko
  • Savolainen, Markku J
  • Scherag, Susann
  • Schipf, Sabine
  • Schreiber, Stefan
  • Schunkert, Heribert
  • Silander, Kaisa
  • Sinisalo, Juha
  • Siscovick, David S
  • Smit, Jan H
  • Soranzo, Nicole
  • Sovio, Ulla
  • Stephens, Jonathan
  • Surakka, Ida
  • Swift, Amy J
  • Tammesoo, Mari-Liis
  • Tardif, Jean-Claude
  • Teder-Laving, Maris
  • Teslovich, Tanya M
  • Thompson, John R
  • Thomson, Brian
  • Tönjes, Anke
  • Tuomi, Tiinamaija
  • van Meurs, Joyce BJ
  • van Ommen, Gert-Jan
  • Vatin, Vincent
  • Viikari, Jorma
  • Visvikis-Siest, Sophie
  • Vitart, Veronique
  • Vogel, Carla IG
  • Voight, Benjamin F
  • Waite, Lindsay L
  • Wallaschofski, Henri
  • Walters, G Bragi
  • Widen, Elisabeth
  • Wiegand, Susanna
  • Wild, Sarah H
  • Willemsen, Gonneke
  • Witte, Daniel R
  • Witteman, Jacqueline C
  • Xu, Jianfeng
  • Zhang, Qunyuan
  • Zgaga, Lina
  • Ziegler, Andreas
  • Zitting, Paavo
  • Beilby, John P
  • Farooqi, I Sadaf
  • Hebebrand, Johannes
  • Huikuri, Heikki V
  • James, Alan L
  • Kähönen, Mika
  • Levinson, Douglas F
  • Macciardi, Fabio
  • Nieminen, Markku S
  • Ohlsson, Claes
  • Palmer, Lyle J
  • Ridker, Paul M
  • Stumvoll, Michael
  • Beckmann, Jacques S
  • Boeing, Heiner
  • Boerwinkle, Eric
  • Boomsma, Dorret I
  • Caulfield, Mark J
  • Chanock, Stephen J
  • Collins, Francis S
  • Cupples, L Adrienne
  • Smith, George Davey
  • Erdmann, Jeanette
  • Froguel, Philippe
  • Grönberg, Henrik
  • Gyllensten, Ulf
  • Hall, Per
  • Hansen, Torben
  • Harris, Tamara B
  • Hattersley, Andrew T
  • Hayes, Richard B
  • Heinrich, Joachim
  • Hu, Frank B
  • Hveem, Kristian
  • Illig, Thomas
  • Jarvelin, Marjo-Riitta
  • Kaprio, Jaakko
  • Karpe, Fredrik
  • Khaw, Kay-Tee
  • Kiemeney, Lambertus A
  • Krude, Heiko
  • Laakso, Markku
  • Lawlor, Debbie A
  • Metspalu, Andres
  • Munroe, Patricia B
  • Ouwehand, Willem H
  • Pedersen, Oluf
  • Penninx, Brenda W
  • Peters, Annette
  • Pramstaller, Peter P
  • Quertermous, Thomas
  • Reinehr, Thomas
  • Rissanen, Aila
  • Rudan, Igor
  • Samani, Nilesh J
  • Schwarz, Peter EH
  • Shuldiner, Alan R
  • Spector, Timothy D
  • Tuomilehto, Jaakko
  • Uda, Manuela
  • Uitterlinden, André
  • Valle, Timo T
  • Wabitsch, Martin
  • Waeber, Gérard
  • Wareham, Nicholas J
  • Watkins, Hugh
  • Procardis Consortium
  • Wilson, James F
  • Wright, Alan F
  • Zillikens, M Carola
  • Chatterjee, Nilanjan
  • McCarroll, Steven A
  • Purcell, Shaun
  • Schadt, Eric E
  • Visscher, Peter M
  • Assimes, Themistocles L
  • Borecki, Ingrid B
  • Deloukas, Panos
  • Fox, Caroline S
  • Groop, Leif C
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  • Hunter, David J
  • Kaplan, Robert C
  • Mohlke, Karen L
  • O'Connell, Jeffrey R
  • Peltonen, Leena
  • Schlessinger, David
  • Strachan, David P
  • van Duijn, Cornelia M
  • Wichmann, H-Erich
  • Frayling, Timothy M
  • Thorsteinsdottir, Unnur
  • Abecasis, Gonçalo R
  • Barroso, Inês
  • Boehnke, Michael
  • Stefansson, Kari
  • North, Kari E
  • McCarthy, Mark I
  • Hirschhorn, Joel N
  • Ingelsson, Erik
  • Loos, Ruth JF
  • et al.

Published Web Location

https://doi.org/10.1038/ng.686Creative Commons 'BY' version 4.0 license
Abstract

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

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