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Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors.

  • Author(s): Miaskowski, Christine;
  • Topp, Kimberly;
  • Conley, Yvette P;
  • Paul, Steven M;
  • Melisko, Michelle;
  • Schumacher, Mark;
  • Chesney, Margaret;
  • Abrams, Gary;
  • Levine, Jon D;
  • Kober, Kord M
  • et al.
Abstract

Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies. Here, we evaluated for differential gene expression (DGE) in peripheral blood between breast cancer survivors with and without PIPN and for neuroinflammatory (NI) related signaling pathways and whole-transcriptome profiles from other experiments. Pathway impact analysis identified 8 perturbed NI related pathways. Expression profile analysis found 15 experiments having similar whole-transcriptome profiles of DGE related to neuroinflammation and PIPN. These findings suggest that perturbations in pathways associated with neuroinflammation are found in cancer survivors with PIPN.

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