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Influence of amyloid and diagnostic syndrome on non‐traditional memory scores in early‐onset Alzheimer's disease
- Bushnell, Justin;
- Hammers, Dustin B;
- Aisen, Paul;
- Dage, Jeffrey L;
- Eloyan, Ani;
- Foroud, Tatiana;
- Grinberg, Lea T;
- Iaccarino, Leonardo;
- Jack, Clifford R;
- Kirby, Kala;
- Kramer, Joel;
- Koeppe, Robert;
- Kukull, Walter A;
- La Joie, Renaud;
- Mundada, Nidhi S;
- Murray, Melissa E;
- Nudelman, Kelly;
- Rumbaugh, Malia;
- Soleimani‐Meigooni, David N;
- Toga, Arthur;
- Touroutoglou, Alexandra;
- Vemuri, Prashanthi;
- Atri, Alireza;
- Day, Gregory S;
- Duara, Ranjan;
- Graff‐Radford, Neill R;
- Honig, Lawrence S;
- Jones, David T;
- Masdeu, Joseph;
- Mendez, Mario;
- Musiek, Erik;
- Onyike, Chiadi U;
- Riddle, Meghan;
- Rogalski, Emily;
- Salloway, Steven;
- Sha, Sharon;
- Turner, Raymond S;
- Wingo, Thomas S;
- Wolk, David A;
- Carrillo, Maria C;
- Dickerson, Bradford C;
- Rabinovici, Gil D;
- Apostolova, Liana G;
- Clark, David G;
- Consortium, the LEADS
- et al.
Published Web Location
https://doi.org/10.1002/alz.13434Abstract
Introduction
The Rey Auditory Verbal Learning Test (RAVLT) is a useful neuropsychological test for describing episodic memory impairment in dementia. However, there is limited research on its utility in early-onset Alzheimer's disease (EOAD). We assess the influence of amyloid and diagnostic syndrome on several memory scores in EOAD.Methods
We transcribed RAVLT recordings from 303 subjects in the Longitudinal Early-Onset Alzheimer's Disease Study. Subjects were grouped by amyloid status and syndrome. Primacy, recency, J-curve, duration, stopping time, and speed score were calculated and entered into linear mixed effects models as dependent variables.Results
Compared with amyloid negative subjects, positive subjects exhibited effects on raw score, primacy, recency, and stopping time. Inter-syndromic differences were noted with raw score, primacy, recency, J-curve, and stopping time.Discussion
RAVLT measures are sensitive to the effects of amyloid and syndrome in EOAD. Future work is needed to quantify the predictive value of these scores.Highlights
RAVLT patterns characterize various presentations of EOAD and EOnonAD Amyloid impacts raw score, primacy, recency, and stopping time Timing-based scores add value over traditional count-based scores.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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