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Tissue States Provide Novel Insights into Attributes that Drive Metastasis

Published Web Location

https://doi.org/10.1016/j.ccr.2011.08.018
Abstract

Recently, in Nature Medicine, Schedin and colleagues define attributes within the involuting postpartum breast microenvironment that promote breast cancer metastasis. Cell invasiveness is controlled by a positive feedback loop involving COX-2 and fibrillar collagen. NSAIDs suppress tumor progression during postpartum involution, potentially providing effective agents for intervention in pregnant women.

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