The purpose of this study was to determine the toxicity tolerance of Drosophila to cadmium in order to obtain flies with a high Cd body burden. CdCl2 was added in various concentrations to the larval rearing medium. Development was normal in media containing less than 102 ug/g Cd (wet wt). Adult flies reared on a medium with 31 ug/g Cd (dry wt) contained an average of 73 ug/g Cd (dry wt). Much of the Cd incorporated into the body of the adult fly was located in the soft tissues and the haemolymph; only negligible amounts were found in the cuticle.