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Open Access Publications from the University of California

Risk Assessment of Internal Malignancies in Patients with Vitiligo

Abstract

• Vitiligo patients were more likely to have a history of a solid-tumor, non-skin cancer and were more likely to have a history of more than 1 cancer type.

• Also, vitiligo patients had a higher likelihood of facing breast, ovary/uterus/cervix, and prostate cancers.

• Significantly decreased risks were noted for lung cancer.

• Patients with unilateral vitiligo were significantly more likely than those with bilateral vitiligo to have a history of a solid-tumor, non-skin cancer, skin cancer, or female breast cancer.

• Our study extends prior registry-based observations by controlling for known cancer risk factors.

• Future directions: Implications for cancer screening, mechanisms involved, time course of the vitiligo and cancer events, and connections to the effects of cancer immunotherapy treatments.