The histopathology of sebaceous carcinoma (SBC) can mimic other skin neoplasms, including basal cell carcinoma (BCC).Therefore, diagnostic biomarkers are needed for a subset of cases. Normal sebaceous glands express PRAME (PRAME nuclearreceptor transcriptional regulator), a melanoma-associated biomarker.Donell et al. showed that PRAME has strong immunoreactivity with basaloid sebocytes in SBC. Ng et al. reported patchy cytoplasmic staining in the germinative sebocytes only.Sebaceous glands (H&E stain and PRAME stain)
Objective: to evaluate the utility of PRAME immunohistochemistry as a diagnostic biomarker for SBC and its usefulness in the distinction of SBC from BCC.
Atypical fibroxanthoma (AFX) is a rare pleomorphic, spindle cell neoplasm that typically presents as a solitary pink/red papule on the head or neck in elderlyindividuals.
Although they rarely metastasize, it is not uncommon for these tumors to locally recur, highlighting the importance of complete removal with negative surgical margins.
Current treatment guidelines recommend Mohs micrographic surgery (MMS) or wide local excision (WLE), yet MMS is generally preferred in clinical practice based on the limited data supporting superior recurrence rates.
However, there are very few studies that have compared these two surgical modalities, and some did not find meaningful differences in the rates of recurrence.
Localized myxedema is a rare complication ofautoimmune thyroid diseases including the Hashimoto thyroiditis and Graves’ disease.Localized myxedema results from the accumulation of glycosaminoglycans in the dermis and subcutaneous layer of the skin.
Fibroblast-produced hyaluronic acid is the mainglycosaminoglycan in localized myxedema. Localized myxedema presents bilaterally with a “boggy” thickening of the skin. Lesions classically have “waxy” swelling and induration.Myxedematous lesions of the skin most often appear on the anterior aspects of the legs and dorsum of the feet. They are often asymptomatic. Targeted treatment to cutaneous lesions is usually reserved for symptomatic cases.
Determine which elements of a lactating patient’s clinical presentation, including breast pump use and symptoms, are associated with a diagnosis of nipple thrush.
Teledermatology is an emerging field withindermatology that has allowed for increased access to care through web portals such as MyChart. MyChart is a password-protected website that offers patients 24-hour access to personal health information and permits patients to send messages and photographs pertaining to their medical concerns.
MMS is a microscopically controlled surgery used to treat skin cancers such as Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), and Melanoma.
Mohs surgeons have increasingly utilized such portals post-operatively to keep track of patient progress2, but there has been sparse research that analyzes the characteristics of patient-initiated electronic and telephone communication after MMS. This study identifies the attributes and factors that contribute to patient-initiated contact after MMS.
