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B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction
- Zouggari, Yasmine;
- Ait-Oufella, Hafid;
- Bonnin, Philippe;
- Simon, Tabassome;
- Sage, Andrew P;
- Guérin, Coralie;
- Vilar, José;
- Caligiuri, Giuseppina;
- Tsiantoulas, Dimitrios;
- Laurans, Ludivine;
- Dumeau, Edouard;
- Kotti, Salma;
- Bruneval, Patrick;
- Charo, Israel F;
- Binder, Christoph J;
- Danchin, Nicolas;
- Tedgui, Alain;
- Tedder, Thomas F;
- Silvestre, Jean-Sébastien;
- Mallat, Ziad
Published Web Location
https://doi.org/10.1038/nm.3284Abstract
After myocardial infarction, inflammatory cells are rapidly recruited to the heart and strongly affect the course of recovery. Ziad Mallat and his colleagues uncover a pathogenic role for B cells after myocardial infarction, showing that infarction triggers B cell secretion of the chemokine Ccl7, which mobilizes monocytes from the bone marrow, increases their recruitment to the heart and impairs heart function.
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