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A culture system to study oligodendrocyte myelination processes using engineered nanofibers
- Lee, Seonok;
- Leach, Michelle K;
- Redmond, Stephanie A;
- Chong, SY Christin;
- Mellon, Synthia H;
- Tuck, Samuel J;
- Feng, Zhang-Qi;
- Corey, Joseph M;
- Chan, Jonah R
Published Web Location
https://doi.org/10.1038/nmeth.2105Abstract
Primary rat oligodendocytes were cultured in the presence of electron-spun nanofibers of varying sizes as a model to study myelination processes in the mammalian central nervous system. The authors study the role of fiber diameter on the initiation of concentric wrapping by oligodendrocytes.
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