Clinical Practice and Cases in Emergency Medicine

Case Presentation: We present the case of a 53-year-old female with darting eye movements and difficulty walking who was found to have opsoclonus-myoclonus syndrome only after multiple presentations to emergency departments over five days.

Discussion: Adult-onset opsoclonus-myoclonus syndrome is a rare central nervous system disease typically associated with paraneoplastic or idiopathic etiologies. With non-specific symptom presentation, this condition is commonly misdiagnosed in adults, leading to diagnostic delays and long-term motor and cognitive sequelae.