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Translation readthrough mitigation
- Arribere, Joshua A;
- Cenik, Elif S;
- Jain, Nimit;
- Hess, Gaelen T;
- Lee, Cameron H;
- Bassik, Michael C;
- Fire, Andrew Z
Published Web Location
https://doi.org/10.1038/nature18308Abstract
Translation termination sequences are occasionally bypassed by the ribosome and the resulting proteins can be detrimental to the cell; here it is shown that cells can prevent such proteins from accumulating through peptides that are encoded within the 3' UTR of genes in both humans and C. elegans.
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