PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms

2022

et al.

Published Web Location

https://doi.org/10.1016/j.cmet.2022.02.008

Creative Commons 'BY' version 4.0 license

Abstract

Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.

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PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms

Published Web Location