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Pharmacovigilance using Clinical Text.
- LePendu, Paea;
- Iyer, Srinivasan V;
- Bauer-Mehren, Anna;
- Harpaz, Rave;
- Ghebremariam, Yohannes T;
- Cooke, John P;
- Shah, Nigam H
Abstract
The current state of the art in post-marketing drug surveillance utilizes voluntarily submitted reports of suspected adverse drug reactions. We present data mining methods that transform unstructured patient notes taken by doctors, nurses and other clinicians into a de-identified, temporally ordered, patient-feature matrix using standardized medical terminologies. We demonstrate how to use the resulting high-throughput data to monitor for adverse drug events based on the clinical notes in the EHR.
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