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Open Access Publications from the University of California

Integrated optical coherence tomography - Ultrasound system and miniaturized probes for intravascular imaging

  • Author(s): Yin, J
  • Li, X
  • Jing, J
  • Hu, C
  • Zhou, Q
  • Burney, T
  • Mukai, D
  • Mahon, S
  • Edris, A
  • Hoang, K
  • Shung, KK
  • Brenner, M
  • Narula, J
  • Chen, Z
  • et al.

Published Web Location Commons Attribution 4.0 International Public License

We report on the development of a multimodal optical coherence tomography (OCT) - ultrasound (US) system and miniaturized OCT-US probe for intravascular imaging. Both OCT optical components and a US transducer were integrated into a single probe, enabling both OCT and US imaging at the same time. A miniaturized OCT-US probe using a single element transducer was designed with a maximum outer diameter of 0.8 mm, which is suitable for in vivo intravascular imaging. The integrated OCT-US imaging system adopted a two-channel data acquisition card to digitize both OCT and US signals. Simultaneous OCT and US data processing and image display were also achieved using our home-developed software. In vitro OCT and US imaging of human aortic tissue was performed using this multimodal imaging system, which demonstrated the feasibility of the OCT-US system in intravascular imaging and its potential in detection of atherosclerotic plaques. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

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