Polyamines and cancer: old molecules, new understanding.
- Author(s): Gerner, Eugene W
- Meyskens, Frank L
- et al.
Published Web Locationhttps://doi.org/10.1038/nrc1454
The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies. Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues.