- Main
Strong Correlation Between Concentrations of Tenofovir (TFV) Emtricitabine (FTC) in Hair and TFV Diphosphate and FTC Triphosphate in Dried Blood Spots in the iPrEx Open Label Extension: Implications for Pre-exposure Prophylaxis Adherence Monitoring
- Gandhi, Monica;
- Team, for the iPrEx Study;
- Glidden, David V;
- Team, for the iPrEx Study;
- Liu, Albert;
- Team, for the iPrEx Study;
- Anderson, Peter L;
- Team, for the iPrEx Study;
- Horng, Howard;
- Team, for the iPrEx Study;
- Defechereux, Patricia;
- Team, for the iPrEx Study;
- Guanira, Juan V;
- Team, for the iPrEx Study;
- Grinsztejn, Beatriz;
- Team, for the iPrEx Study;
- Chariyalertsak, Suwat;
- Team, for the iPrEx Study;
- Bekker, Linda-Gail;
- Team, for the iPrEx Study;
- Grant, Robert M;
- Team, for the iPrEx Study;
- Team, for the iPrEx Study;
- Lama, Javier;
- Schechter, Mauro;
- Kallas, Esper G;
- Veloso, Valdilea;
- Mayer, Kenneth;
- Buchbinder, Susan;
- Montoya, Orlando;
- Amico, Rivet;
- Koester, Kim;
- Mulligan, Kathy;
- Casapia, Martin;
- Benet, Leslie Z;
- Huang, Yong;
- Yee, Shirley;
- Kuncz, Karen;
- Louie, Alexander;
- Francisco, San;
- Greenblatt, Ruth;
- Tien, Phyllis;
- Aouizerat, Bradley
Published Web Location
https://doi.org/10.1093/infdis/jiv239Abstract
Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P < .001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P < .001); hair FTC/DBS TFV-DP (r = 0.74; P < .001); hair FTC/DBS FTC-TP (r = 0.587; P < .001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.