Skip to main content
Download PDF
- Main
Precipitous Deterioration of Motor Function, Cognition, and Behavior
- Fernández-Fournier, Mireya;
- Perry, David C;
- Tartaglia, Maria Carmela;
- de May, Mary;
- Boxer, Adam;
- Coppola, Giovanni;
- Christine, Chadwick W;
- Huang, Eric J;
- Seeley, William W;
- Miller, Bruce L;
- DeArmond, Steven J;
- Grinberg, Lea T;
- Geschwind, Michael D
Published Web Location
https://doi.org/10.1001/jamaneurol.2016.6159Abstract
A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and started walking cautiously. After 1 year, her depression resolved but she developed a dry cough. One year later, she experienced a more rapid decline in her gait with parkinsonism, visual difficulties with restricted vertical gaze, slowed horizontal and vertical saccades, dysphagia, apathy, and progressive cognitive decline, which led to her death 2 years later. The differential diagnosis, neuroimaging, and pathological findings are discussed, as well as their public health implications.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.