Brain metastases in osteosarcoma: incidence, clinical and neuroradiological findings and management options
Published Web Location
https://doi.org/10.1007/bf00163540
Abstract
Brain metastasis is uncommon in osteosarcoma, but this may be changing with prolonged patient survival in the modern chemotherapy era. We present 5 patients with brain metastases out of 39 with lung metastasis (13%) in a total of 87 osteosarcoma patients.The clinical manifestations of brain metastases were catastrophic: massive hemorrhage in 2 and status epilepticus in 3. Metastases were single or multiple, and some were osteoblastic. Surgical intervention in 2 cases resulted in dramatic, though transient, clinical improvement.We advocate periodic neuroradiology screening in osteosarcoma patients with lung metastases, for early detection of brain involvement.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.