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Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
- Williams, Amy L;
- Jacobs, Suzanne BR;
- Moreno-Macías, Hortensia;
- Huerta-Chagoya, Alicia;
- Churchhouse, Claire;
- Márquez-Luna, Carla;
- García-Ortíz, Humberto;
- José Gómez-Vázquez, María;
- Burtt, Noël P;
- Aguilar-Salinas, Carlos A;
- González-Villalpando, Clicerio;
- Florez, Jose C;
- Orozco, Lorena;
- Haiman, Christopher A;
- Tusié-Luna, Teresa;
- Altshuler, David;
- Williams, Amy L;
- Márquez-Luna, Carla;
- Huerta-Chagoya, Alicia;
- Ripke, Stephan;
- José Gómez-Vázquez, María;
- Manning, Alisa K;
- Moreno-Macías, Hortensia;
- García-Ortíz, Humberto;
- Neale, Benjamin;
- Burtt, Noël P;
- Aguilar-Salinas, Carlos A;
- Reich, David;
- Stram, Daniel O;
- Fernández-López, Juan Carlos;
- Romero-Hidalgo, Sandra;
- Altshuler, David;
- Florez, Jose C;
- Tusié-Luna, Teresa;
- Patterson, Nick;
- Haiman, Christopher A;
- Aguilar-Delfín, Irma;
- Martínez-Hernández, Angélica;
- Centeno-Cruz, Federico;
- Mendoza-Caamal, Elvia;
- Revilla-Monsalve, Cristina;
- Islas-Andrade, Sergio;
- Córdova, Emilio;
- Rodríguez-Arellano, Eunice;
- Soberón, Xavier;
- Orozco, Lorena;
- Florez, Jose C;
- González-Villalpando, Clicerio;
- González-Villalpando, María Elena;
- Haiman, Christopher A;
- Henderson, Brian E;
- Monroe, Kristine;
- Wilkens, Lynne;
- Kolonel, Laurence N;
- Le Marchand, Loic;
- Riba, Laura;
- Ordóñez-Sánchez, María Luisa;
- Rodríguez-Guillén, Rosario;
- Cruz-Bautista, Ivette;
- Rodríguez-Torres, Maribel;
- Muñoz-Hernández, Linda Liliana;
- Sáenz, Tamara;
- Gómez, Donají;
- Alvirde, Ulices;
- Burtt, Noël P;
- Onofrio, Robert C;
- Brodeur, Wendy M;
- Gage, Diane;
- Murphy, Jacquelyn;
- Franklin, Jennifer;
- Mahan, Scott;
- Ardlie, Kristin;
- Crenshaw, Andrew T;
- Winckler, Wendy;
- Prüfer, Kay;
- Shunkov, Michael V;
- Sawyer, Susanna;
- Stenzel, Udo;
- Kelso, Janet;
- Lek, Monkol;
- Sankararaman, Sriram;
- Williams, Amy L;
- Patterson, Nick;
- MacArthur, Daniel G;
- Reich, David;
- Derevianko, Anatoli P;
- Pääbo, Svante;
- Jacobs, Suzanne BR;
- Churchhouse, Claire;
- Gopal, Shuba;
- Grammatikos, James A;
- Smith, Ian C;
- Bullock, Kevin H;
- Deik, Amy A;
- Souza, Amanda L;
- Pierce, Kerry A;
- Clish, Clary B;
- Altshuler, David;
- Fennell, Timothy;
- Farjoun, Yossi;
- Genomics Platform*, Broad;
- Gabriel, Stacey;
- Stram, Daniel O;
- Gross, Myron D;
- Pereira, Mark A;
- Seielstad, Mark;
- Koh, Woon-Puay;
- Tai, E-Shyong;
- Flannick, Jason;
- Fontanillas, Pierre;
- Morris, Andrew;
- Teslovich, Tanya M;
- Burtt, Noël P;
- Atzmon, Gil;
- Blangero, John;
- Bowden, Donald W;
- Chambers, John;
- Shin Cho, Yoon;
- Duggirala, Ravindranath;
- Glaser, Benjamin;
- Hanis, Craig;
- Kooner, Jaspal;
- Laakso, Markku;
- Lee, Jong-Young;
- Tai, E-Shyong;
- Ying Teo, Yik;
- Wilson, James G;
- Haiman, Christopher A;
- Henderson, Brian E;
- Monroe, Kristine;
- Wilkens, Lynne;
- Kolonel, Laurence N;
- Le Marchand, Loic;
- Puppala, Sobha;
- Farook, Vidya S;
- Thameem, Farook;
- Abboud, Hanna E;
- DeFronzo, Ralph A;
- Jenkinson, Christopher P;
- Lehman, Donna M;
- Curran, Joanne E;
- Blangero, John;
- Duggirala, Ravindranath;
- Burtt, Noël P;
- Cortes, Maria L;
- Altshuler, David;
- Florez, Jose C;
- Haiman, Christopher A;
- Henderson, Brian E;
- Aguilar-Salinas, Carlos A;
- González-Villalpando, Clicerio;
- Orozco, Lorena;
- Tusié-Luna, Teresa
Published Web Location
https://doi.org/10.1038/nature12828Abstract
A risk haplotype for type 2 diabetes is identified with four amino acid substitutions in SLC16A11, which is present at ∼50% frequency in Native American samples and ∼10% in east Asian samples, but is rare in European and African samples; SLC16A11 may alter hepatic lipid metabolism, causing an increase in triacylglycerol levels.
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