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Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity
- Carmi, Yaron;
- Spitzer, Matthew H;
- Linde, Ian L;
- Burt, Bryan M;
- Prestwood, Tyler R;
- Perlman, Nicola;
- Davidson, Matthew G;
- Kenkel, Justin A;
- Segal, Ehud;
- Pusapati, Ganesh V;
- Bhattacharya, Nupur;
- Engleman, Edgar G
Published Web Location
https://doi.org/10.1038/nature14424Abstract
Naturally occurring tumour-binding IgG antibodies are shown to initiate the rejection of allogeneic tumours, whereby Fc-receptor-mediated uptake of tumour immune complexes into dendritic cells activates tumour-reactive T cells, and intra-tumoral injection of allogeneic IgG together with dendritic cell adjuvants induces systemic T-cell-mediated antitumour responses.
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