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Fastest Time to Cancer by Loss of Tumor Suppressor Genes or Oncogene Activation

Creative Commons 'BY' version 4.0 license

Genetic instability promotes cancer progression (by increasing the probability of cancerous mutations) as well as hinders it (by imposing a higher cell death rate for cells susceptible to cancerous mutation).

With oncogene activation or the loss of tumor suppressor gene functions known to be responsible for a high percentage of breast and colorectal cancer (and a good fraction of lung cancer and other types as well), it is important to understand how genetic instability can be orchestrated toward carcinogenesis. In this context, this research gives a complete characterization of the optimal cell mutation rate for the fastest time to a target cancerous cell population through the loss of both copies of a tumor suppressor gene or through oncogene activation.

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