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Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system
- Workman, Michael J;
- Mahe, Maxime M;
- Trisno, Stephen;
- Poling, Holly M;
- Watson, Carey L;
- Sundaram, Nambirajan;
- Chang, Ching-Fang;
- Schiesser, Jacqueline;
- Aubert, Philippe;
- Stanley, Edouard G;
- Elefanty, Andrew G;
- Miyaoka, Yuichiro;
- Mandegar, Mohammad A;
- Conklin, Bruce R;
- Neunlist, Michel;
- Brugmann, Samantha A;
- Helmrath, Michael A;
- Wells, James M
Published Web Location
https://doi.org/10.1038/nm.4233Abstract
Organoids formed by combining pluripotent-stem-cell-derived human neural crest cells with pluripotent-stem-cell-derived intestinal tissue show functional interstitial cells of Cajal and undergo waves of contraction; these tissues reveal insights into the molecular defects characterizing Hirschsprung's disease.
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