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Glucose feeds the TCA cycle via circulating lactate
- Hui, Sheng;
- Ghergurovich, Jonathan M;
- Morscher, Raphael J;
- Jang, Cholsoon;
- Teng, Xin;
- Lu, Wenyun;
- Esparza, Lourdes A;
- Reya, Tannishtha;
- Le Zhan;
- Yanxiang Guo, Jessie;
- White, Eileen;
- Rabinowitz, Joshua D
Published Web Location
https://doi.org/10.1038/nature24057Abstract
Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.
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