Butler enables rapid cloud-based analysis of thousands of human genomes.
- Author(s): Yakneen, Sergei
- Waszak, Sebastian M
- PCAWG Technical Working Group
- Gertz, Michael
- Korbel, Jan O
- PCAWG Consortium
- et al.
Published Web Locationhttps://doi.org/10.1038/s41587-019-0360-3
We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.