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Butler enables rapid cloud-based analysis of thousands of human genomes.

  • Author(s): Yakneen, Sergei
  • Waszak, Sebastian M
  • PCAWG Technical Working Group
  • Gertz, Michael
  • Korbel, Jan O
  • PCAWG Consortium
  • et al.

We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

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