Skip to main content
eScholarship
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation.

  • Author(s): Shimizu, Renee E
  • Connolly, Patrick M
  • Cellini, Nicola
  • Armstrong, Diana M
  • Hernandez, Lexus T
  • Estrada, Rolando
  • Aguilar, Mario
  • Weisend, Michael P
  • Mednick, Sara C
  • Simons, Stephen B
  • et al.
Abstract

Sounds associated with newly learned information that are replayed during non-rapid eye movement (NREM) sleep can improve recall in simple tasks. The mechanism for this improvement is presumed to be reactivation of the newly learned memory during sleep when consolidation takes place. We have developed an EEG-based closed-loop system to precisely deliver sensory stimulation at the time of down-state to up-state transitions during NREM sleep. Here, we demonstrate that applying this technology to participants performing a realistic navigation task in virtual reality results in a significant improvement in navigation efficiency after sleep that is accompanied by increases in the spectral power especially in the fast (12-15 Hz) sleep spindle band. Our results show promise for the application of sleep-based interventions to drive improvement in real-world tasks.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View