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A split active site couples cap recognition by Dcp2 to activation

Published Web Location

https://doi.org/10.1038/nsmb.1879
Abstract

Dcp2 mediated decapping of mRNAs is a key step in 5'-3' transcript decay. Using NMR-based analysis, it is now shown that the cap is recognized by two distinct regions in the regulatory and catalytic domains of Dcp2. This argues that cap recognition involves these regions coming together, in a step promoted by the regulatory factor Dcp1, thus leading to catalysis.

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