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Discovery of new GPCR ligands to illuminate new biology

Published Web Location

https://doi.org/10.1038/nchembio.2490
Abstract

Structure-based computational methods have contributed to recent successes in the development of small molecules to study GPCR function and to act as therapeutics, including the identification of new ligands for orphan GPCRs, allosteric regulators, and biased ligands.

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