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Genetics of rheumatoid arthritis contributes to biology and drug discovery
- Okada, Yukinori;
- Wu, Di;
- Trynka, Gosia;
- Raj, Towfique;
- Terao, Chikashi;
- Ikari, Katsunori;
- Kochi, Yuta;
- Ohmura, Koichiro;
- Suzuki, Akari;
- Yoshida, Shinji;
- Graham, Robert R;
- Manoharan, Arun;
- Ortmann, Ward;
- Bhangale, Tushar;
- Denny, Joshua C;
- Carroll, Robert J;
- Eyler, Anne E;
- Greenberg, Jeffrey D;
- Kremer, Joel M;
- Pappas, Dimitrios A;
- Jiang, Lei;
- Yin, Jian;
- Ye, Lingying;
- Su, Ding-Feng;
- Yang, Jian;
- Xie, Gang;
- Keystone, Ed;
- Westra, Harm-Jan;
- Esko, Tõnu;
- Metspalu, Andres;
- Zhou, Xuezhong;
- Gupta, Namrata;
- Mirel, Daniel;
- Stahl, Eli A;
- Diogo, Dorothée;
- Cui, Jing;
- Liao, Katherine;
- Guo, Michael H;
- Myouzen, Keiko;
- Kawaguchi, Takahisa;
- Coenen, Marieke JH;
- van Riel, Piet LCM;
- van de Laar, Mart AFJ;
- Guchelaar, Henk-Jan;
- Huizinga, Tom WJ;
- Dieudé, Philippe;
- Mariette, Xavier;
- Louis Bridges Jr, S;
- Zhernakova, Alexandra;
- Toes, Rene EM;
- Tak, Paul P;
- Miceli-Richard, Corinne;
- Bang, So-Young;
- Lee, Hye-Soon;
- Martin, Javier;
- Gonzalez-Gay, Miguel A;
- Rodriguez-Rodriguez, Luis;
- Rantapää-Dahlqvist, Solbritt;
- Ärlestig, Lisbeth;
- Choi, Hyon K;
- Kamatani, Yoichiro;
- Galan, Pilar;
- Lathrop, Mark;
- Eyre, Steve;
- Bowes, John;
- Barton, Anne;
- de Vries, Niek;
- Moreland, Larry W;
- Criswell, Lindsey A;
- Karlson, Elizabeth W;
- Taniguchi, Atsuo;
- Yamada, Ryo;
- Kubo, Michiaki;
- Liu, Jun S;
- Bae, Sang-Cheol;
- Worthington, Jane;
- Padyukov, Leonid;
- Klareskog, Lars;
- Gregersen, Peter K;
- Raychaudhuri, Soumya;
- Stranger, Barbara E;
- De Jager, Philip L;
- Franke, Lude;
- Visscher, Peter M;
- Brown, Matthew A;
- Yamanaka, Hisashi;
- Mimori, Tsuneyo;
- Takahashi, Atsushi;
- Xu, Huji;
- Behrens, Timothy W;
- Siminovitch, Katherine A;
- Momohara, Shigeki;
- Matsuda, Fumihiko;
- Yamamoto, Kazuhiko;
- Plenge, Robert M
Published Web Location
https://doi.org/10.1038/nature12873Abstract
A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future.
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