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Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
Published Web Location
https://doi.org/10.1039/d3sc00198aAbstract
Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and are safe and green, and rely on Nature-inspired thioesters that are then converted to the targeted functionality.
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