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Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
- Fancy, Stephen PJ;
- Harrington, Emily P;
- Yuen, Tracy J;
- Silbereis, John C;
- Zhao, Chao;
- Baranzini, Sergio E;
- Bruce, Charlotte C;
- Otero, Jose J;
- Huang, Eric J;
- Nusse, Roel;
- Franklin, Robin JM;
- Rowitch, David H
Published Web Location
https://doi.org/10.1038/nn.2855Abstract
Premyelinating oligodendrocytes are vulnerable to hypoxic injuries, especially during the neonatal period. Here, Fancy et al. find that the Wnt scaffolding molecule Axin2 is crucial for normal remyelination after hypoxic injuries and demonstrate that pharmacological inhibition of tankyrase, which stabilizes Axin2 levels, can promote oligodendrocyte differentiation and recovery after hypoxic and demyelinating injuries.
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