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X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

Published Web Location

https://doi.org/10.1039/c7cc00783c
Abstract

The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.

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