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Nitro sulfonyl fluorides are a new pharmacophore for the development of antibiotics

et al.

Published Web Location

https://doi.org/10.1039/c8me00011e
Abstract

The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa.

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