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Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.

  • Author(s): Dixon, Suzanne C
  • Nagle, Christina M
  • Wentzensen, Nicolas
  • Trabert, Britton
  • Beeghly-Fadiel, Alicia
  • Schildkraut, Joellen M
  • Moysich, Kirsten B
  • deFazio, Anna
  • Australian Ovarian Cancer Study Group
  • Risch, Harvey A
  • Rossing, Mary Anne
  • Doherty, Jennifer A
  • Wicklund, Kristine G
  • Goodman, Marc T
  • Modugno, Francesmary
  • Ness, Roberta B
  • Edwards, Robert P
  • Jensen, Allan
  • Kjær, Susanne K
  • Høgdall, Estrid
  • Berchuck, Andrew
  • Cramer, Daniel W
  • Terry, Kathryn L
  • Poole, Elizabeth M
  • Bandera, Elisa V
  • Paddock, Lisa E
  • Anton-Culver, Hoda
  • Ziogas, Argyrios
  • Menon, Usha
  • Gayther, Simon A
  • Ramus, Susan J
  • Gentry-Maharaj, Aleksandra
  • Pearce, Celeste Leigh
  • Wu, Anna H
  • Pike, Malcolm C
  • Webb, Penelope M
  • et al.
Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited.Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths).Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)).Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

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