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The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator.

  • Author(s): Bakolitsa, Constantina;
  • Bateman, Alex;
  • Jin, Kevin K;
  • McMullan, Daniel;
  • Krishna, S Sri;
  • Miller, Mitchell D;
  • Abdubek, Polat;
  • Acosta, Claire;
  • Astakhova, Tamara;
  • Axelrod, Herbert L;
  • Burra, Prasad;
  • Carlton, Dennis;
  • Chiu, Hsiu Ju;
  • Clayton, Thomas;
  • Das, Debanu;
  • Deller, Marc C;
  • Duan, Lian;
  • Elias, Ylva;
  • Feuerhelm, Julie;
  • Grant, Joanna C;
  • Grzechnik, Anna;
  • Grzechnik, Slawomir K;
  • Han, Gye Won;
  • Jaroszewski, Lukasz;
  • Klock, Heath E;
  • Knuth, Mark W;
  • Kozbial, Piotr;
  • Kumar, Abhinav;
  • Marciano, David;
  • Morse, Andrew T;
  • Murphy, Kevin D;
  • Nigoghossian, Edward;
  • Okach, Linda;
  • Oommachen, Silvya;
  • Paulsen, Jessica;
  • Reyes, Ron;
  • Rife, Christopher L;
  • Sefcovic, Natasha;
  • Tien, Henry;
  • Trame, Christine B;
  • Trout, Christina V;
  • van den Bedem, Henry;
  • Weekes, Dana;
  • White, Aprilfawn;
  • Xu, Qingping;
  • Hodgson, Keith O;
  • Wooley, John;
  • Elsliger, Marc André;
  • Deacon, Ashley M;
  • Godzik, Adam;
  • Lesley, Scott;
  • Wilson, Ian A
  • et al.
Abstract

The crystal structure of Jann_2411 from Jannaschia sp. strain CCS1, a member of the Pfam PF07336 family classified as a domain of unknown function (DUF1470), was solved to a resolution of 1.45 Å by multiple-wavelength anomalous dispersion (MAD). This protein is the first structural representative of the DUF1470 Pfam family. Structural analysis revealed a two-domain organization, with the N-terminal domain presenting a new fold called the ABATE domain that may bind an as yet unknown ligand. The C-terminal domain forms a treble-clef zinc finger that is likely to be involved in DNA binding. Analysis of the Jann_2411 protein and the broader ABATE-domain family suggests a role as stress-induced transcriptional regulators.

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