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The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator
- Bakolitsa, Constantina;
- Bateman, Alex;
- Jin, Kevin K;
- McMullan, Daniel;
- Krishna, S Sri;
- Miller, Mitchell D;
- Abdubek, Polat;
- Acosta, Claire;
- Astakhova, Tamara;
- Axelrod, Herbert L;
- Burra, Prasad;
- Carlton, Dennis;
- Chiu, Hsiu-Ju;
- Clayton, Thomas;
- Das, Debanu;
- Deller, Marc C;
- Duan, Lian;
- Elias, Ylva;
- Feuerhelm, Julie;
- Grant, Joanna C;
- Grzechnik, Anna;
- Grzechnik, Slawomir K;
- Han, Gye Won;
- Jaroszewski, Lukasz;
- Klock, Heath E;
- Knuth, Mark W;
- Kozbial, Piotr;
- Kumar, Abhinav;
- Marciano, David;
- Morse, Andrew T;
- Murphy, Kevin D;
- Nigoghossian, Edward;
- Okach, Linda;
- Oommachen, Silvya;
- Paulsen, Jessica;
- Reyes, Ron;
- Rife, Christopher L;
- Sefcovic, Natasha;
- Tien, Henry;
- Trame, Christine B;
- Trout, Christina V;
- van den Bedem, Henry;
- Weekes, Dana;
- White, Aprilfawn;
- Xu, Qingping;
- Hodgson, Keith O;
- Wooley, John;
- Elsliger, Marc-André;
- Deacon, Ashley M;
- Godzik, Adam;
- Lesley, Scott;
- Wilson, Ian A
- et al.
Published Web Location
https://doi.org/10.1107/s1744309109025196Abstract
The crystal structure of Jann_2411 from Jannaschia sp. strain CCS1, a member of the Pfam PF07336 family classified as a domain of unknown function (DUF1470), was solved to a resolution of 1.45 Å by multiple-wavelength anomalous dispersion (MAD). This protein is the first structural representative of the DUF1470 Pfam family. Structural analysis revealed a two-domain organization, with the N-terminal domain presenting a new fold called the ABATE domain that may bind an as yet unknown ligand. The C-terminal domain forms a treble-clef zinc finger that is likely to be involved in DNA binding. Analysis of the Jann_2411 protein and the broader ABATE-domain family suggests a role as stress-induced transcriptional regulators.
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