UCSF

Key PointsThe brain controls the function of neural circuits and networks, in part, by modulating the synchrony of their components.Network hypersynchrony and altered oscillatory rhythmic activity may underlie cognitive abnormalities in Alzheimer disease (AD).In AD, network activities that support cognition are altered decades before clinical disease onset, and the affected networks predict future pathology and brain atrophy.Although the precise causes and pathophysiological consequences of these network alterations remain to be fully elucidated, interneuron dysfunction and network abnormalities have emerged as potential mechanisms of cognitive dysfunction in AD and related disorders.Several lines of evidence suggest that modulating interneuron-dependent network alterations could be a useful therapeutic strategy to improve brain functions in these conditions.