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Open Access Publications from the University of California

Gender differences in cortical glucose metabolism in Alzheimer's disease and normal aging

  • Author(s): Siegel, BV
  • Shihabuddin, L
  • Buchsbaum, MS
  • Starr, A
  • Haier, RJ
  • Valladares Neto, DC
  • et al.

Male Alzheimer's disease patients, studied with 18-fluoro-2-deoxyglucose positron emission tomography while performing a verbal memory test, showed a right-greater-than-left asymmetry of cortical metabolism that tended to be greater than that in healthy, age-matched control subjects. This asymmetry was absent in female patients, preliminarily suggesting a propensity for left hemispheric involvement in the Alzheimer's disease process in males.

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