O'Bryant, Sid E; Johnson, Leigh A; Barber, Robert C; Braskie, Meredith N; Christian, Bradley; Hall, James R; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa; Philips, Nicole; Rissman, Robert A; Shi, Yonggang; Toga, Arthur W; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, Kristine; Team, for the HABLE Study

doi:10.1002/dad2.12202

Download PDF

The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics

Published Web Location

https://doi.org/10.1002/dad2.12202

Abstract

Introduction

Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature.

Methods

Community-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository.

Results

Data was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites.

Discussion

The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content

For improved accessibility of PDF content, download the file to your device.

UCSF